Annalise challenges her students to solve some of the most difficult criminal cases, and selects a group of the smartest students to come work for her. Meanwhile, in flash-forwards, we learn that a group of four students, Wes, Connor, Michaela and Laurel get involved in their own murder mystery cover up.

Annalise and her students must move on with their lives as though nothing has happened, but the students are still reeling over Rebecca's disappearance. Only Annalise and Frank know that Rebecca was murdered and the two are determined to find out who killed her. Meanwhile, Annalise decides she wants to take on a new client, a brother and sister who are accused of killing their parents, and an old friend surprises Annalise at home and teaches her a valuable lesson.

With Wallace Mahoney's murder unsolved and Frank's whereabouts unknown, the "Keating 5" struggle to move on with their lives as they enter into their second year of law school. Meanwhile, Annalise's reputation at Middleton University is on the line, so she creates a criminal law clinic where the students will compete to try their own pro bono cases. Annalise also wrestles with a decision involving Frank that could change everything.

In the wake of Wes’ tragic death, Annalise returns to her family home to pick up the pieces of her shattered life, and realizes that, in order to rebuild, she must make a tough and shocking decision. Meanwhile, “the Keating 4” all face an uncertain future while Laurel becomes obsessed with finding out what actually happened to Wes the night he died. In a flash-forward, a terrifying crime is committed and everyone is a suspect.

Annalise selects students for her new legal clinic at Middleton and juggles job offers from competing firms, all while the Keating 4 attempt to move on from last semester’s turmoil. And in a startling flash-forward, a new mystery is introduced and it shakes things up for everyone.

Annalise struggles with the personal toll that Laurel and Christopher's disappearance has taken on everyone. Meanwhile, the remaining Keating 4, Oliver, Frank and Bonnie disagree on the possible reasons behind Laurel's disappearance. Tegan handles the aftermath of Emmett's apparent poisoning, and Gabriel wants to take his budding relationship with Michaela to the next level.